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Trial to Study Effect of Gabapentin on Pain of Second Cataract Surgery

Hyperalgesia, or increased sensitivity to pain, occurring at the second operation in staged bilateral cataract surgery is well documented.

The details of a study by Seoul National University Hospital recently published to clinicaltrials.gov will evaluate the effectiveness of pretreatment with gabapentin after the first operation on reduction of pain at second operation. Gabapentin is a drug originally developed to treat epilepsy that is currently used to relieve pain.

Click here for details of the study.

Trial to Study Treatment of Geographic Atrophy with Emixustat Hydrochloride

Emixustat Hydrochloride is an orally dosed compound produced by Acucela in development for the treatment of geographic atrophy (GA) associated with dry age-related macular degeneration (AMD).

Recently published to clinicaltrials.gov were details of a multi-center, randomized, masked, multiple-dose, crossover study of the pharmacokinetics of emixustat hydrochloride in subjects with GA associated with dry AMD.

Click here for details.

Does Eye Rubbing Cause Keratoconus?

Ideally, the cornea should be spherical, but in some patients the cornea gets deformed to a cone shape – a condition known as keratoconus. Keratoconus may cause blurring of vision which may require the use of a rigid contact lens or surgical intervention.

It’s been thought that eye rubbing – a behavior very common in patients with eczema and other chronic allergic conditions – when done constantly every few minutes over many years may lead to permanent …

DREAM Study to Evaluate Omega-3 Fatty Acids in Treatment of Dry Eye

On April 28, 2014, details were submitted to clinicaltrials.gov of the DREAM study (Dry Eye Assessment and Management Study).

There is a hypothesis that omega-3 supplementation is an effective treatment for Dry Eye Disease (DED). The objective of the DREAM study is to evaluate that hypothesis by testing the effectiveness and safety of omega-3 fatty acid supplementation in relieving symptoms of moderate to severe dry eye disease in a randomized, double blind clinical trial.

The primary outcome measure …

A New Approach for Repairing/Rejuvenating Damaged Photoreceptors

The use of retinal progenitor cells to repair or rejuvenate damaged or destroyed photoreceptors (rods and cones) to restore vision in those with lost vision due to photoreceptor damage is now possible and will soon be starting human clinical testing.

Among the companies involved in research in this area are jCyte, Advanced Cell Technology (ACTC), ReNeuron and California Stem Cell.

To read the complete story, please follow this link.

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Glaucoma

Allergan Webinar: Open-Angle Glaucoma: Managing IOP in Clinical Practice

Allergan, together with the Consortium of Research and Education, is sponsoring live one (1) hour webinars entitled “Open-Angle Glaucoma: Managing IOP in Clinical Practice.”

The webinars will be presented by prominent glaucoma specialists on the following dates and times:

  • February 7, 2013 – 12:30 PM ET (Thomas Mundorf, MD, Mundorf Eye Center, Charlotte, NC).
  • February 11, 2013 – 12:30 PM ET (Robert Rothman, MD, Glaucoma Consultants of Long Island, Lake Success, NY).
  • February 13, 2013 – 3:30 PM ET

List of Clinical Trials Evaluating Use of Stem Cells to Treat Eye Diseases

Irv Aron has compiled a comprehensive list of clinical trials evaluating the use of stem cells in treating various eye diseases. The list, which includes links to relevant pages on the National Institutes of Health Clinical Trials website, should be a very helpful resource for eyecare patients who wish to determine whether they are eligible to participate in particular trials.

These clinical trials will hopefully help unlock the potential of stem cells to restore vision to …

Eye Injury From Laser Eyebrow Removal

Archives: Researchers report five case reports of inadvertent injury to the eye from laser eyebrow removal. The cases included iritis, glaucoma (mostly pigment-related), pupil distortion and cataract, ultimately requiring surgery. This occurred despite wearing goggles- it seems if the fit is not perfect, the laser energy can seep through and attack the pigmented structures of the eyes.  Caution is therefore advised.

Risk of Hyperglycemia From Steroids Is Low

Ophthalmology: Every doctor fears the risk of steroids, including hypertension and high blood sugar. But a study suggests the risk is less than we fear. A study of patients with inflammatory eye disease placed on steroids showed that only about 1%, highest in older patients and blacks, were placed on hypoglycemic medication. True, perhaps some were not seen by their doctors and therefore not counted in this study. We should remain cautious, but perhaps we …

Where In God’s Name Should We Perform the Iridectomy?!

I was taught to put the iridectomy superiorly where it’s covered by the lid and therefore unlikely to cause symptoms from stray light. Then years later, I became aware of problems precisely at this location, especially when only partially covered by the lid, due to the prismatic effect of the tear meniscus, and so I started doing them temporally. I was also told a too-small iridectomy may diffract light and make symptoms worse. Now, an …

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Cataract

Trial to Study Effect of Gabapentin on Pain of Second Cataract Surgery

Hyperalgesia, or increased sensitivity to pain, occurring at the second operation in staged bilateral cataract surgery is well documented.

The details of a study by Seoul National University Hospital recently published to clinicaltrials.gov will evaluate the effectiveness of pretreatment with gabapentin after the first operation on reduction of pain at second operation. Gabapentin is a drug originally developed to treat epilepsy that is currently used to relieve pain.

Click here for details of the study.

Discovery About Shape of the Eye Could Boost Effectiveness of Artificial Lenses Used in Cataract Surgery

Professor Barbara Pierscionek, the Associate Dean of Research and Enterprise at Kingston’s Faculty of Science, Engineering and Computing, has devoted two decades to researching the biochemical, optical and mechanical properties of the eye’s lens.

Last week, Professor Pierscionek and her team announced research findings suggesting that the way proteins are distributed in the lens of the eye may cause its gradient to be stepped rather than smooth as previously thought. The findings could provide new insight …

Is It Better to Have Cataract Surgery on Both Eyes or One Eye?

The latest issue of Ophthalmology from the American Academy of Ophthalmology reported on a study finding that second-eye cataract surgery may result in better visual functioning than single-eye surgery.

Studying nearly 1,800 patients who had not yet undergone surgery for cataract, researchers concluded that unilateral cataract surgery (i.e., surgery in one eye) improves visual functioning, the largest gains are found in patients who undergo second-eye cataract surgery. As such, they recommended second-eye cataract surgery for patients …

Alcon Launches ILEVRO™ for Treatment of Pain and Inflammation Associated with Cataract Surgery

Last week, Alcon announced the launch of ILEVRO™ Suspension (nepafenac ophthalmic suspension 0.3%) as a once-daily treatment option for pain and inflammation associated with cataract surgery.

According to Alcon’s release, in two double masked, randomized clinical trials, ILEVRO™ Suspension demonstrated superior clinical efficacy compared to its vehicle; i.e., patients treated with ILEVRO™ Suspension were less likely to have ocular pain and measurable signs of inflammation (cells and flare) at the end of treatment than those treated …

Eye Injury From Laser Eyebrow Removal

Archives: Researchers report five case reports of inadvertent injury to the eye from laser eyebrow removal. The cases included iritis, glaucoma (mostly pigment-related), pupil distortion and cataract, ultimately requiring surgery. This occurred despite wearing goggles- it seems if the fit is not perfect, the laser energy can seep through and attack the pigmented structures of the eyes.  Caution is therefore advised.

Also...

Cornea

Does Eye Rubbing Cause Keratoconus?

Ideally, the cornea should be spherical, but in some patients the cornea gets deformed to a cone shape – a condition known as keratoconus. Keratoconus may cause blurring of vision which may require the use of a rigid contact lens or surgical intervention.

It’s been thought that eye rubbing – a behavior very common in patients with eczema and other chronic allergic conditions – when done constantly every few minutes over many years may lead to permanent …

Diagnosing Limbal Stem Cell Deficiency Associated With Contact Lens Wear

There are numerous eye conditions associated with contact lens wear (see helpful summary in this 2010 article).

An article in the March 2013 issue of the American Journal of Ophthalmology examined the characteristics of patients with severe limbal stem cell deficiency associated with contact lens wear and possible therapies.

The article concluded that in severe cases of LSCD, conservative measures may not reverse the disease, and limbal stem cell transplantation with systemic immunosuppression should be …

List of Clinical Trials Evaluating Use of Stem Cells to Treat Eye Diseases

Irv Aron has compiled a comprehensive list of clinical trials evaluating the use of stem cells in treating various eye diseases. The list, which includes links to relevant pages on the National Institutes of Health Clinical Trials website, should be a very helpful resource for eyecare patients who wish to determine whether they are eligible to participate in particular trials.

These clinical trials will hopefully help unlock the potential of stem cells to restore vision to …

Cross-Linking Using Excimer Laser Delivers Better Results Than Mechanical Debridement

Ophthalmology: Collagen cross-linking has been shown to improve corneal curvature in diseases like keratoconus. The epithelium often is removed first, and researchers have shown that using the excimer laser to do this is better than mechanical debridement, with better astigmatism using the former.

Yellow Corneal Rings From AMD Supplements

Yellow rings may be noticeable from patients taking supplements for macular degeneration, probably from the carotene, according to a group from University of Pittsburgh. Not to be confused with Fleischer rings (which I finally saw once in the Kings County clinic last year). Patients may also have yellowish skin. Just another thing to look out for, or something to make yourself look good when asked by a colleague or attending for a differential diagnosis of …

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Retina

Trial to Study Treatment of Geographic Atrophy with Emixustat Hydrochloride

Emixustat Hydrochloride is an orally dosed compound produced by Acucela in development for the treatment of geographic atrophy (GA) associated with dry age-related macular degeneration (AMD).

Recently published to clinicaltrials.gov were details of a multi-center, randomized, masked, multiple-dose, crossover study of the pharmacokinetics of emixustat hydrochloride in subjects with GA associated with dry AMD.

Click here for details.

A New Approach for Repairing/Rejuvenating Damaged Photoreceptors

The use of retinal progenitor cells to repair or rejuvenate damaged or destroyed photoreceptors (rods and cones) to restore vision in those with lost vision due to photoreceptor damage is now possible and will soon be starting human clinical testing.

Among the companies involved in research in this area are jCyte, Advanced Cell Technology (ACTC), ReNeuron and California Stem Cell.

To read the complete story, please follow this link.

Gene Therapy in Ophthalmology Tables Updated

I received some information about a new effort in using gene therapy for treating choroideremia (and other ocular diseases), started by a group in Canada, The Alberta Ocular Gene Therapy Team, at the University of Alberta, and along with the news about the spin-out of Spark Therapeutics from the Children’s Hospital of Philadelphia (CHOP), decided it was time to update my gene therapy tables.

The updated tables are now online, and can be accessed via …

Stem Cells/Cell Therapy in Ophthalmology Tables Updated

Thanks to an effort underway (and to be published in December by Mark Hellin, editor of The Ophthalmologist (UK), I learned of several new clinical trials (and companies/institutions) involved in using stem cells in treating ophthalmic disorders. Thus, with the new additions, I decided to update my online tables of stem cell use in ophthalmology.

The latest versions of the three tables list all of the companies/institutions involved, the applications being researched, and the status of …

DARPins Phase 2 Trial Results Fall Short

Back in February, I first reported on Allergan’s DARPins in my Update 23: DARPins, The Next “Game Changer” for Wet AMD. In that report, I wrote that Molecular Partners’ MPO112 (Allergan’s AGN-150998) showed promise of improving vision and having a long ocular half-life which appeared to be a vast improvement over both Lucentis and Eylea, perhaps requiring injections every 3-4 months compared to bi-monthly for Eylea and monthly for Lucentis and Avastin. (I also noted …

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Refractive

Can ACTC’s Stem Cells be Used to Treat Severe Myopia?

Advanced Cell Technology, Inc. (OTCBB: ACTC) announced last week that one of its clinical trial partners, UCLA’s Jules Stein Eye Institute, has received FDA approval of its Investigational New Drug (IND) Application to initiate a Phase I/II study using ACTC’s retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs) to treat severe myopia (commonly known as nearsightedness).

The primary focus of the study will be to evaluate the safety in patients with severe myopia …

Diagnosing Limbal Stem Cell Deficiency Associated With Contact Lens Wear

There are numerous eye conditions associated with contact lens wear (see helpful summary in this 2010 article).

An article in the March 2013 issue of the American Journal of Ophthalmology examined the characteristics of patients with severe limbal stem cell deficiency associated with contact lens wear and possible therapies.

The article concluded that in severe cases of LSCD, conservative measures may not reverse the disease, and limbal stem cell transplantation with systemic immunosuppression should be …

Google Glasses Ready for Rollout (Developers Only For Now)

Project Glass is Google’s initiative to develop futuristic, Internet-connected glasses that show digital information right in front of your eyes, projected over the physical world, including directions, messages, and more.

Although they are not for sale quite yet, the company recently announced that it is holding events in New York City and San Fransisco where it will give software and app developers an opportunity to use the spectacles, and suggest software ideas and tie-ins. Alas, consumers …

Blurry Vision With AcrySof IQ Toric IOL

I had the AcrySof® IQ Toric IOL lens implanted in both eyes 2 years ago. They were mono vision implants. OD is fine. I had a “piggyback implant” done to the OD one year following the implant to the OD. OS is blurry and I cannot read. Almost as if there is an opaqueness on the periphery. Had an angiogram of the eyes and there is a slight occulsion to a small …

New Campaign to Build Consumer Awareness of Visian ICL as a Vision Correction Alternative to LASIK

We’ve blogged before about the effectiveness of the Visian ICL from STAAR Surgical Company (Nasdaq: STAA).

STAAR yesterday announced the launch of new global consumer awareness initiatives for the Visian® ICL product line. The initiatives include a redesigned consumer-friendly web site, increased support for practices and distributors for their own Visian ICL awareness campaigns and added consumer marketing in Asia.

Visian ICL is a vision correction alternative to LASIK involving …

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Stem Cell Therapies

Stem Cells/Cell Therapy in Ophthalmology Tables Updated

Thanks to an effort underway (and to be published in December by Mark Hellin, editor of The Ophthalmologist (UK), I learned of several new clinical trials (and companies/institutions) involved in using stem cells in treating ophthalmic disorders. Thus, with the new additions, I decided to update my online tables of stem cell use in ophthalmology.

The latest versions of the three tables list all of the companies/institutions involved, the applications being researched, and the status of …

Patient Advisory for Stem Cell Therapy and Medical Tourism

CIRM – California Institute for Regenerative Medicine

August 19, 2013

(This article was just posted on the CIRM (California Stem Cell Agency’s website) and is an important notice to all thinking about traveling to a foreign nation to undergo stem cell treatment. It should be read in its entirety before throwing out your money!)

As stakeholders in cellular therapy, the undersigned professional organizations believe it is necessary to share the following important message with patients and families contemplating …

A New Virus Vector for Safer Delivery of Gene Therapies in Ophthalmology

Researchers at UCal Berkeley have found a gene therapy vector that can deliver genes deep into the retina via intravitreous delivery, instead of using a needle to deliver the virus sub-retinally.

This eliminates the need for a vitrectomy, anesthesia and a hospital stay to treat patients, allowing for a simple short office visit and injection into the vitreous, similar to the way anti-VEGF drugs for age-related macular degeneration are currently delivered.

To read more, please follow this …

Patient in ACTC Stem Cell Clinical Trial With Dry AMD Goes from Legally Blind (20/400) to Near Normal Vision (20/40)

As you may know, Advanced Cell Technology is currently running three stem cell clinical trials; two for treating Stargardt’s Disease, one in the U.S. and one in the UK; and one clinical trial in the U.S. for treating the dry form of AMD.

Due to a unique set of circumstances, it was disclosed that one of the …

Current Status of Stem Cells and Gene Therapy in Ophthalmology

In the past couple of months, I was asked to update an article I wrote on stem cells in ophthalmology, originally published in Retina Today, for its sister publication, Advanced Ocular Care, and to write a similar article about the current status of gene therapy for another ophthalmic publication, Retinal Physician. These two articles have now been published in the respective journals and made available online.

Here is a brief summary of each article, along with …

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