Retinal ganglion cells (RGCs) often become dysfunctional following the onset of glaucoma before there is even any vision loss. Thus, it is important to detect the destruction of retinal ganglion cells as early as possible.

In a study conducted at the Bascom Palmer Eye Institute at the University of Miami’s Miller School of Medicine, researchers found that by using a steady-state pattern electroretinogram known as PERGLA, they were able to detect destruction of retinal ganglion cells earlier than had previously been possible – in time to allow vision correcting surgery that can reverse the damage. Specifically, after reduction of intraocular pressure via a trabeculectomy or drainage implant surgery, researchers saw electrophysiologic improvements in the responses of dysfunctional or damaged ganglion cells.

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