As reported at the AAO this week, Malik Y. Kahook, M.D., warned that post-operative IOP spikes following Avastin® injection may be due to components used at the compounding pharmacy.

He feels that some component used in the compounding techniques may lead to either an immunologic process or the aggregation of larger proteins/compounds that may block trabecular outflow.

While investigation is ongoing as to similar occurrences with Lucentis®, there is an overwhelming association with Avastin®.

What does this mean? I am more curious as to the definition of the IOP spike.  I am also wondering how often patients are generally seen after an injection?

Any comments?

Randall V. Wong, M.D.
www.RetinaEyeDoctor.com ^[1]
Retina Specialist