In the past few years, one or two articles came out that suggested that that the time-honored practice of doing a monocular trial to check the IOP lowering effect just doesn’t work. It seems that there is just too much variability in IOP between the eyes and on a day-to-day/diurnal basis. An article in this month’s Ophthalmology seems to be the final nail in that coffin. I abandoned the trial a couple of years ago and am relieved that I did the right thing.