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Advanced Cell Technology, OHSU Researchers Show Safety, Efficacy of Human Embryonic Stem Cell (hESC)-Derived Retinal Pigment Epithelium (RPE)

Posted By Dr. Dominique Walton Brooks On June 25, 2009 @ 10:34 am In Industry News,Macular Degeneration,New Technologies,Research,Retina,Stem Cell Therapies | Comments Disabled

Advanced Cell Technology, Inc. and researchers at Oregon Health & Science University have reported the long-term safety and efficacy of human embryonic stem cell (hESC)-derived retinal pigment epithelium (RPE) cells. These cells are considered suitable for human trials and were tested in different in vitro and animal models.

The studies were performed in the RCS rat, an animal in which the vision deteriorates due to an RPE functional defect. After 3 months, the treated retina had 5-6 layers of photoreceptors while the untreated animals only had a single layer of cells left. The researchers also showed that vision could be rescued in a mouse model of Stargardt’s disease.

Two important early applications for these cells will be for the treatment of age-related macular degeneration and Stargardt’s disease.

For more information, read the full press release here [1] or the abstract and article here [2] (log in required) in the journal Stem Cells.


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URL to article: http://eyedocnews.com/001393-advanced-cell-technology-ohsu-researchers-show-safety-efficacy-of-human-embryonic-stem-cell-hesc-derived-retinal-pigment-epithelium-rpe/

URLs in this post:

[1] here: http://www.eurekalert.org/pub_releases/2009-06/act-aos060909.php

[2] here: http://www3.interscience.wiley.com/journal/122455604/abstract

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